汤其群教授

    汤其群,教授,博士生导师。1990年毕业于上海医科大学法医学系, 1995年获得上海医科大学生物化学与分子生物学博士学位,同年赴美国Johns Hopkins大学医学院生物化学系作博士后。2002年受聘为Johns Hopkins大学医学院儿科内分泌系助理教授兼生化系助理教授。2005年6月辞去美国的职位,全职受聘于复旦大学。曾担任复旦大学上海医学院副院长;现任复旦大学基础医学院院长,生物医学研究院副院长,分子医学教育部重点实验室主任;中国生物化学与分子生物学会副理事长,中国医学生物化学与分子生物学协会副理事长。
    汤其群教授为第二批教育部“长江学者奖励计划”特聘教授(1999),为国家自然科学基金委“杰出青年基金”获得者(2006),为国家重大科学研究计划“干细胞定向分化的基础与临床应用研究”的首席科学家,2005年入选上海市首批“医学领军人才”,2007年入选上海市领军人才,并被评为优秀学科带头人,2009年入选国家“百千万人才计划”国家级人选, 2010年被Johns Hopkins大学生物化学系聘为兼职教授(Adjunct Professor),被美国中华医学基金会评为CMB杰出教授。目前担任美国生物化学杂志(Journal of Biological Chemistry)编委。

 

主要研究方向
1、脂肪细胞发育分化机理研究 。
2、肥胖相关代谢性疾病防治研究。

 

代表性论文(*通讯作者)
1.Huang HY, Zhang WT, Jiang WY, Chen SZ, Liu Y, Ge X, Li X, Dang YJ, Wen B, Liu XH, Lu HJ, Qi-Qun Tang*. RhoGDIβ Inhibits Bone Morphogenetic Protein 4 (BMP4)-induced Adipocyte Lineage Commitment and Favors Smooth Muscle-like Cell Differentiation. J Biol Chem. 2015 Apr 24;290(17):11119-29
2.Guo L, Li X, Qi-Qun Tang*. Transcriptional regulation of adipocyte differentiation: a central role for CCAAT/enhancer-binding protein (C/EBP) β. J Biol Chem. 2015 Jan 9;290(2):755-61
3.Yan Jiang, Liang Guo, Li-Qi Xie, You-You Zhang, Xiao-Hui Liu, Yang Zhang, Hao Zhu, Peng- Yuan Yang, Hao-Jie Lu, Qi-Qun Tang*.  Proteome profiling of mitotic clonal expansion during 3T3-L1 adipocyte differentiation using iTRAQ-2DLC-MS/MS. J. Proteome Res. 2014 Mar 7;13(3):1307-14.
4.Liang Guo, Jia-Xin Huang, Yuan Liu, Xi Li, Shui-Rong Zhou, Shu-Wen Qian, Yang Liu,  Hao Zhu, Hai-Yan Huang, Yong-Jun Dang, Qi-Qun Tang*.  Transactivation of Atg4b by C/EBPβ Promotes Autophagy to Facilitate Adipogenesis.  Mol Cell Biol. 2013; 33(16):3180-90
5.Yuan Liu, Zhi-Chun Zhang, Shu-Wen Qian, You-you Zhang, Hai-yan Huang, Yan Tang1, Liang Guo1, Xi Li, and Qi-Qun Tang*. MicroRNA-140 promotes adipocyte lineage commitment of C3H10T1/2 pluripotent stem cell via targeting Osteopetrosis-associated transmembrane protein 1. J. Biol. Chem. 2013;288(12):8222-30
6.Shu-wen Qian, Yan Tang, Xi Li, Yuan Liu, You-you Zhang, Hai-yan Huang, Rui-Dan Xue, Hao-yong Yu, Liang Guo, Hui-di Gao, Yan Liu, Xia Sun, Yi-ming Li, Wei-Ping Jia, Qi-Qun Tang*.  BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci USA. 2013;110(9):E798-807
7.Liang Guo, Xi Li, Jia-Xin Huang, Hai-Yan Huang, You-You Zhang, Shu-Wen Qian, Hao Zhu, Ya-Dong Zhang, Yang Liu, Yuan Liu, Kan-Kan Wang, Qi-Qun Tang*. Histone Demethylase Kdm4b Functions as a Co-Factor of C/EBPβ to Promote Mitotic Clonal Expansion During Differentiation of 3T3-L1 Preadipocytes. Cell Death Differ. 2012;19(12): 1917-1927.
8.Qi-Qun Tang, M. Daniel Lane, Adipogenesis: From stem cell to adipocyte. Annu Rev Biochem. 2012; 81:715-736.
9.You-you Zhang, Xi Li, Shu-wen Qian, Liang Guo, Hai-yan Huang, Qun He, Yuan Liu, Chun-Gu Ma, and Qi-Qun Tang*. Down-regulation of type I runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis. Mol Endocrinol. 2012;26(5): 798-808.
10.You-You Zhang, Xi Li, Shu-Wen Qian, Liang Guo, Hai-Yan Huang, Qun He, Yuan Liu, Chun-Gu Ma, and Qi-Qun Tang*. Transcriptional activation of histone H4 by C/EBP during the mitotic clonal expansion of 3T3-L1 adipocyte differentiation. Mol Biol Cell. 2011;22: 2165-74.
11.Hai-Yan Huang, Ling-Ling Hu, Tan-Jing Song, Xi Li, Qun He, Xia Sun, Yi-Ming Li, Hao-Jie Lu, Peng-Yuan Yang, and Qi-Qun Tang*. Involvement of cytoskeleton-associated proteins in the commitment of C3H10T1/2 pluripotent stem cells to adipocyte lineage induced by BMP2/4. Mol Cell Proteomics. 2011;10(1): 1-8.
12.Haiyan Huang, Tan-Jing Song, Xi Li, Lingling Hu, Qun He, Mei Liu, M. Daniel Lane, Qi-Qun Tang*. The BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage, Proc Natl Acad Sci USA. 2009; 106: 12670-5.
13.Xi Li, Henrik Molina, Haiyan Huang, You-you Zhang, Mei Liu, Shu-wen Qian, Chad Slawson, Wagner B. Dias, Akhilesh Pandey, Gerald W. Hart, M. Daniel Lane, Qi-Qun Tang*. O-linked N-acetylglucosamine modification on C/EBProle during adipocyte differentiation, J. Biol. Chem. 2009;284: 19248-19254.

 

主要承担课题
课题负责人在研的科研项目
课题来源                 课题编号               
国家科技部            2006CB943700 (国家重大科学研究计划,首席科学家)
国家科技部            2011CB910201 (国家重大科学研究计划,课题负责人)
国家自然科学基金     31030048      (国家杰出青年项目,课题负责人)

 

主要授权的专利
1、 一种N末端缺失脂肪细胞补体相关蛋白及其制备方法 2005 第一完成人
专利号:ZL01126950.2
2、 一种多肽gapM1及其制备方法(2011) 第一完成人
专利号:200510025128.4

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