查锡良教授

       

          

    查锡良 (1949~),浙江海宁人。教授,博士生导师。1987年获上海医科大学生物化学专业博士学位。曾在美国密执安大学医学院生化系作博士后研究和加拿大马尼托巴大学医学院生化与分子生物学系作访问学者,并多次至香港、美国、日本、瑞士和韩国等进行学术访问及参加国际学术会议。现任中国生物化学与分子生物学会副理事长。
    长期从事医学生物化学与分子生物学、糖蛋白N-糖链结构与功能、肿瘤分子生物学等领域的教学和科研工作,1998年以来共发表国内外学术论文60余篇。主编卫生部研究生规划教材《医学分子生物学》与卫生部本科生规划教材《生物化学》等,参编多部学术专著。作为课题负责人或主要参与者,近年来承担了一系列国家自然科学基金面上项目、重点项目、863项目、973项目、上海市教委重点项目和美国CMB项目;作为上海市优秀学科带头人承担多项上海市科委项目。作为第一完成人共获上海市科技进步奖二等奖等奖项5项。曾获复旦大学优秀研究生导师、卫生部中青年医学科技之星,卫生部有突出贡献的中青年专家,宝钢优秀教师奖,教育部全国优秀教师等殊荣。
代表性文章:
1. Yu-Long Liang, Yi Fu, Si-Gang Chen, Xiu-Mei Cai, Jin-Min Su, Li-Ying Wang, Heng Wu, Dong-Zhu Ma, Zhen Xu, Xi-Liang Zha. Integrin beta1 subunit overexpressed in the SMMC-7721 cells regulates the promoter activity of p21^CIP1 and enhances its transcription FEBS Lett, 2004, 558(1-3): 107-113
2. Cai XM, Tao BB, Wang LY, Liang YL, Jin JW, Yang Y, Hu YL, Zha XL. Protein phosphatase activity of PTEN inhibited the invasion of glioma cells with epidermal growth factor receptor mutation type III expression. Int J Cancer. 2005 Jun 28; 117:905-912
3. Liying Wang, Yulong Liang, Zengxia Li, Xiumei Cai, Wen Zhang, Guoqiang Wu, Jiawei Jin, Zhengyu Fang, Yong Yang, Xiliang Zha GnT-V promotes fibronectin-based cell motility via enhancement of integrin β1 stability in hepatocarcinoma cells J Cellular Biochemistry 100:230–241 (2007)
4. Nan Wu, Wen Zhang, Yu-Long Liang, Li-Ying Wang, Jia-Wei Jin, Xiu-Mei Cai, and Xi-Liang Zha. Profilin 1 obtained by proteomic analysis in all-trans retinoic acid-treated hepatocarcinoma cell lines was associated with inhibition of cell proliferation and migration. Proteomics 2006, 6:6095-6106
5. Zhibin Xu, Xinwen Zhou, Haojie Lu, Nan Wu, Hongbo Zhao, Lineng Zhang, Wen Zhang, Yu Long Liang, Liying Wang, Yinkun Liu, Pengyuan Yang, and Xiliang Zha. Comparative Glycoproteomics Based on Lectins Affinity Capture of N-linked Glycoproteins from Human Chang Liver Cells and MHCC97H Cells.Proteomics 7:2358-2370,2007
6. Lidong Sun, Hongbo Zhao, Zhibin Xu, Qinglan Liu, Yulong Liang, Liying Wang, Xiumei Cai, Lineng Zhang, Libing Hu, Guomin Wang, Xiliang Zha Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation Cellular Signaling 19:2255-2263,2007
7. Can Wang, Zengxia Li, Zhaohua Yang, Hongbo Zhao,Yong Yang, Kangli Chen,1 Xiumei Cai,1 Liying Wang,1,2* Yinghong Shi,4 Shuangjian Qiu, Jia Fan, and Xiliang Zha1 The Effect of Receptor Protein Tyrosine Phosphatase Kappa on the Change of Cell Adhesion and Proliferation Induced by N-Acetylglucosaminyltransferase V J Cell Biochem 2010 109:113–123
8. Chuanzhong Mei, Lidong Sun, Yonglei Liu, Yong Yang, Xiumei Cai, Mingzhu Liu, Wantong Yao, Can Wang, Xin Li. Liying Wang, Zengxia Li, Yinghong Shi, Shuangjian Qiu, Jia Fan, Xiliang Zha Transcriptional and Post-transcriptional Control of DNA Methyltransferase 3B Is Regulated by Phosphatydylinositol 3 Kinase/Akt Pathway in Human Hepatocellular Carcinoma Cell Lines J Cell Biochem 2010 111:158–167

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