丁忠仁研究员

 

           

                           

 

    丁忠仁,研究员,博士生导师。1990年毕业于河南医科大学医学系, 1998年获得中山医科大学药理学博士学位,2000年赴美国Temple大学医学院生理学系作博士后。2005年受聘为Temple大学医学院Sol Sherry血栓中心助理科学家。2007年9月辞去美国的职位,全职受聘于复旦大学。
    为上海市教委首批首轮 “上海高校特聘教授(东方学者)”(2008年),长期从事血小板激活机制、抗血小板药作用机理和抗血小板药的新药研发工作,在2011年7月在日本京都举行的“第23届国际血栓与止血学会大会” (International Society on Thrombosis and Haemostasis ⅩⅩⅢ Congress,ISTH 2011)上,该课题组两名研究生同时获得两项“青年研究学者奖”(Young Investigator Award)。对血小板NOD2受体的研究被Circulation作为当期唯一的“Feathered work”推介,同时配发哈佛大学医学院Tsokos教授写的Editorial,认为该成果和同期发表的另一篇文章共同解决了当今医学临床中的两个重要问题(“The two accompanying papers address two important points in the current practice of medicine”).
    承担国家自然科学基金(面上项目)4项、上海市科委“浦江计划”人才项目1项、科技部和上海市科委新药创制子课题各1项,

 

主要研究方向
1、血小板激活机制;
2、抗血小板药作用机理的新药研发;
3、血小板相关性疾病的发病机制及防治研究。

 

代表性论文
1.Jianqin Ye, Lili Zhai, Shenghui Zhang, Yan Zhang, Leilei Chen, Liang Hu, Si Zhang, Zhongren Ding*. Dl-3-n-butylphthalide inhibits platelet activation via inhibition of cPLA2-mediated TXA2 synthesis and phosphodiesterase. Platelets. 2015 (Epub ahead of print, doi:10.3109/09537104.2014.989826)
2.Si Zhang, Shenghui Zhang, Liang Hu, Lili Zhai, Ruyi Xue, Jianqin Ye, Leilei, Chen, Jozef S. Mruk, Guanjun Cheng, Satya P. Kunapuli, Zhongren Ding*. Nucleotide-Binding Oligomerization Domain 2 Receptor Is Expressed in Platelets and Enhances Platelet Activation and ThrombosisIs. Circulation .2015; 131(13): 1160 - 1170 (Featured work with an editorial)
3.Lei Liu, Jian Li, Yan Zhang, Shenghui Zhang, Jianqin Ye, Zhichao Wen, Jianping Ding, Satya P. Kunapuli, Xinping Luo*, Zhongren Ding*. Salvianolic acid B inhibits platelets as a P2Y12 antagonist and PDE inhibitor: evidence from clinic to laboratory. Thromb Res. 2014; 134(4): 866 - 76
4.Shenghui Zhang, Yan Zhang, Jian Shen, Si Zhang, Leilei Chen, Jianxin Gu, Guanjun Cheng, Jozef S. Mruk, Li Zhu, Satya P. Kunapuli, Zhongren Ding*. Tumor vascular disrupting agent DMXAA inhibits platelet activation and thrombosis via inhibition of TXA2 signaling and phosphodiesterase. J Thromb Haemost. 2013; 11(10): 1855 - 1866
5.Si Zhang, Jianqin Ye, Yan Zhang, Xiaofeng Xu, Junling Liu, Shenghui Zhang, Satya P. Kunapuli, Zhongren Ding*. P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation. J Thromb Haemost. 2013; 11(1): 149 -160
6.Yan Zhang, Jianqin Ye, Liang Hu, Si Zhang, Shenghui Zhang, Yimin Li, Satya P. Kunapuli, Zhongren Ding*. Increased platelet activation and thrombosis in transgenic mice expressing constitutively active P2Y12 receptor. J Thromb Haemost. 2012; 10(10): 2149 - 2157
7.ChangE Pan, Xuebin Wei*, Jianqin Ye, Guocheng Liu, Si Zhang, Yan Zhang, Hongguang Du, Zhongren Ding*. BF066, a novel dual target antiplatelet agent without significant bleeding. PloS One. 2012; 7: e40451
8.Liang Hu, Zhichao Fan, Hongguang Du, Ran Ni, Si Zhang, Kanhua Yin, Jianqin Ye, Yan Zhang, Xunbin Wei, Xiaohui Zhang, Peter L. Gross, Satya P. Kunapuli, Zhongren Ding*. BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase. Thromb Haemost. 2011; 106(6): 1203 - 14
9.Si Zhang, Liang Hu, Hongguang Du, Yan Guo, Yan Zhang, Haixia Niu, Jianguo Jin, Jian Zhang, Junling Liu, Xiaohui Zhang, Satya P. Kunapuli, Zhongren Ding*. BF0801, a novel adenine derivative, inhibits platelet activation via phosphodiesterase inhibition and P2Y12 antagonism. Thromb Haemost.2010; 104(4): 845 - 57 (cover figure)

 

主要承担课题
课题负责人在研的科研项目
课题来源               课题编号               
国家自然科学基金       81402920 (青年基金项目)
国家自然科学基金       81373411 (面上项目)
国家自然科学基金       81173053 (面上项目)

 

授权专利
1、丁忠仁, 胡亮, 张思, 杜洪光。一种双功能抗小板聚集药物及其用途。专利号:201110034492.2。

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