李希教授

 

    李希(1976~) 重庆人,教授,博士生导师。1998年南京大学本科毕业获学士学位,2003年获南京大学生理专业博士学位,2006~2007年赴美国Johns Hopkins大学医学院生化系做访问学者,现任复旦大学基础医学院教授。目前担任中国生物化学与分子生物学会医学分会青年委员,上海市生物化学与分子生物学会理事。
    李希教授2008年入选“上海市优秀青年科技启明星计划”,2013年获得“上海市优秀青年科技启明星跟踪计划”,2009年入选“教育部新世纪人才计划”,2012年入选“上海市卫生局新优青培养计划”。李希教授作为课题负责人承担了国家自然科学基金等多项课题,发表学术论文48篇,作为第一作者/通讯作者在PNAS、MCB、JBC等高水平杂志发表论文19篇。

 

主要研究方向:
1.脂肪细胞发育分化过程中的基因转录调控、表观遗传调控
2.代谢相关疾病的分子机理研究

 

代表性论文(*通讯作者)
1.Zhi-Chun Zhang, Yuan Liu, Shu-Fen Li, Liang Guo, Yue Zhao, Shu-Wen Qian, Bo Wen, Qi-Qun Tang, Xi Li*. Suv39h1 mediates AP-2α-dependent inhibition of C/EBPα expression during adipogenesis. Mol Cell Biol. 2014;34(12):2330-8
2.Yue Zhao, Ya-Dong Zhang, You-You Zhang, Shu-Wen Qian, Zhi-Chun Zhang, Shu-Fen Li, Liang Guo, Yuan Liu, Bo Wen, Qun-Ying Lei Qi-Qun Tang, Xi Li*,p300-Dependent Acetylation of ATF5 Enhances C/EBPβ Transactivation of C/EBPα During 3T3-L1 Differentiation. Mol Cell Biol. 2014;34(3):315-324
3.Xi Li, Rong Zeng, Qi-Qun Tang*. Evaluation of protein phosphorylation during adipogenesis. Methods in Enzymology. 2014;538:279-295
4.Shu-fen Li, Liang Guo, Shu-wen Qian, Yuan Liu, You-You Zhang, Zhi-Chun Zhang, Yue Zhao, Jian-Yong Shou, Qi-Qun Tang, Xi Li*. G9a is Transactivated by C/EBPβ to Facilitate Mitotic Clonal Expansion during 3T3-L1 Preadipocyte Differentiation. Am J Physiol Endocrinol Metab. 2013; 304(9): E990-E998
5.Yuan Liu, Zhi-Chun Zhang,Shu-wen Qian, You-you Zhang, Hai-yan Huang, Yan Tang, Liang Guo, Xi Li*. and Qi-qun Tang*, MicroRNA-140 promotes adipocyte lineage commitment of C3H10T1/2 pluripotent stem cell via targeting Osteopetrosis-associated transmembrane protein 1. J. Biol. Chem. 2013; 288(12): 8222-30
6.Yuan-Yuan Zhang, Shu-Fen Li, Shu-Wen Qian, You-You Zhang, Yuan Liu, Qi-Qun Tang, Xi Li*. Phosphorylation prevents C/EBPfrom the calpain-dependent degradation. Biochem Biophys Res Commun.2012; 419 (3) : 550-555(10)
7.You-You Zhang, Xi Li*, Shu-Wen Qian, Liang Guo, Hai-Yan Huang, Qun He, Yuan Liu, Chun-Gu Ma, and Qi-Qun Tang*. Transcriptional activation of histone H4 by C/EBP during the mitotic clonal expansion of 3T3-L1 adipocyte differentiation. Molecular Biology of the Cell. 2011;22: 2165-74(14)
8.Xi Li, Henrik Molina, Haiyan Huang, You-you Zhang, Mei Liu, Shu-wen Qian, Chad Slawson, Wagner B. Dias, Akhilesh Pandey, Gerald W. Hart, M. Daniel Lane, Qi-Qun Tang*.O-linked N-acetylglucosamine modification on CCAAT enhancer binding protein: role during adipocyte differentiation. J. Biol. Chem. 2009;284: 19248-19254
9.Xi Li, Jae-Woo Kim, Mads Gronborg, Henning Urlaub,M Daniel Lane*, Qi-Qun Tang. Role of cdk2 in the Sequential Phosphorylation/activation of C/EBP during adipocyte differentiation. Proc Natl Acad Sci USA. 2007;104: 11597-602.


主要承担课题
课题负责人在研的科研项目
课题来源                课题编号       
科技部                  2013CB530601(973计划)
国家自然科学基金           81270954 (面上项目)
上海市科委               13QH1400800 (启明星跟踪计划)
上海市卫生局            XYQ2011037(新优青计划)

 

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