刘贇 研究员

 

刘贇,研究员,博士生导师。

 

课题组主页: liulab.fudan.edu.cn

 

主要研究方向

1. DNA甲基化在肿瘤及常见疾病(如类风湿关节炎、酒精成瘾等)发生中的作用
2. DNA甲基化作为分子标志物在疾病临床诊疗中的运用

 

代表性论文 (*通讯作者)

 

6. Qiu, W., Xu, Z., Zhang, M., Zhang, D., Fan, H., Li, T., Wang, Q., Liu, P., Zhu, Z., Du, D., Tan, M., Wen, B., Liu, Y.* Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system. Nucleic Acids Res. (2019) doi: 10.1093/nar/gkz134 (影响因子: 11.56)

 

5. Zhu, Z., Meng, W., Liu, P., Zhu, X., Liu, Y.*, Zou, H.* DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding. Clin Epigenetics. (2017) 9:99

 

4. Meng, W.#, Zhu, Z.#, Jiang, X., Too, CL., Uebe, S., Jagodic, M., Kockum, I., Murad, S., Ferrucci, L., Alfredsson, L., Zou, H., Klareskog, L., Feinberg, AP., Ekström, TJ., Padyukov, L.*, Liu, Y.* DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis. Arthritis Res Ther (2017) 19:71

 

3. Liu, Y.#, Li, X.#, Aryee, MJ., Ekstrom, TJ., Padyukov, L., Klareskog, L., Vandiver, A., Moore, AZ., Tanaka, T., Ferrucci, L., Fallin, MD., Feinberg, AP. GeMes: Clusters of DNA methylation under genetic control can inform genetic and epigenetic analysis of disease. Am J Hum Genet, (2014) 94:485-495 (影响因子: 11.2)

 

2Liu, Y.#, Aryee, MJ.#, Padyukov, L.#, Fallin, MD.#, Hesselberg, E., Runarsson, A., Reinius, L., Acevedo, N., Taub, M., Ronninger, M., Shchetynsky, K., Scheynius, A., Kere, J., Alfredsson, L., Klareskog, L.*, Ekstrom, TJ.*, and Feinberg, AP*. Epigenome-wide association data implicate DNA methylation as an intermediary of generic risk in Rheumatoid Arthritis. Nat. Biotechnol., (2013) 31:142-147 (影响因子: 32.44)

 

1. Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. and Desiderio, S. A Plant Homeodomain in RAG-2 that Binds Hypermethylated Lysine 4 of Histone H3 is Necessary For Efficient Antigen-Receptor-Gene Rearrangement. Immunity, (2007) 27:561-571 (封面故事, 影响因子: 21.64)

 

版权所有:复旦大学代谢分子医学教育部重点实验室  技术支持:维程信息  电话:(021) 54237739
通讯地址:上海市医学院路138号238信箱  邮编:200032  Email:fenziyixue@yahoo.cn  传真:(021) 64033738