黄海艳 副教授

 

 

    黄海艳,博士, 副教授,硕导。1998年获中国医科大学医学学士学位,2001年获中国医科大学医学硕士学位。2006年获复旦大学生物化学和分子生物学专业博士学位。 2004~2005年赴美国Johns Hopkins大学医学院生化系联合培养1年。博士毕业后留校,主要研究多潜能干细胞定向分化的分子机制及其在代谢综合征中的作用,揭示多潜能干细胞向前 脂肪细胞定向过程中的重要事件及关键蛋白和对代谢过程的影响。迄今,作为第一作者和共同通讯作者发表相关SCI论文10余篇,包括:Proc Natl Acad Sci U S A,Mol Cell Proteomics,J Biol Chem 等杂志。

 

主要研究方向
多潜能干细胞定向分化的分子机制及其在代谢综合征中的作用

 

代表性论文(*共同通讯作者)
1.Huang HY*, Zhang WT, Jiang WY, Chen SZ, Liu Y, Ge X, Li X, Dang YJ, Wen B, Liu XH, Lu HJ, Tang QQ.RhoGDIβ Inhibits Bone Morphogenetic Protein 4 (BMP4)-induced Adipocyte Lineage Commitment and Favors Smooth Muscle-like Cell Differentiation. J Biol Chem. 2015 Apr 24;290(17):11119-29.
2.Huang HY*, Chen SZ, Zhang WT, Wang SS, Liu Y, Li X, Sun X, Li YM, Wen B, Lei QY, Tang QQ. Induction of EMT-like response by BMP4 via up-regulation of lysyl oxidase is required for adipocyte lineage commitment. Stem Cell Res. 2013; 10(3):278-87. doi: 10.1016/j.scr.2012.12.005.
3.Wang SS, Huang HY*, Chen SZ, Li X, Liu Y, Zhang WT, Tang QQ. Early growth response 2 (Egr2) plays opposing roles in committing C3H10T1/2 stem cells to adipocytes and smooth muscle-like cells. Int J Biochem Cell Biol. 2013;45(8):1825-32. doi: 10.1016/j.biocel.2013.06.003.
4.Huang HY, Hu LL, Song TJ, Li X, He Q, Sun X, Li YM, Lu HJ, Yang PY, Tang QQ. Involvement of cytoskeleton-associated proteins in the commitment of C3H10T1/2 pluripotent stem cells to adipocyte lineage induced by BMP2/4. Mol Cell Proteomics. 2011 Jan;10(1):M110.002691. doi: 10.1074/mcp.M110.002691.
5.Huang H, Song TJ, Li X, Hu L, He Q, Liu M, Lane MD, Tang QQ. BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12670-5. doi: 10.1073/pnas.0906266106.
6.He Q, Huang HY*, Zhang YY, Li X, Qian SW, Tang QQ. TAZ is downregulated by dexamethasone during the differentiation of 3T3-L1 preadipocytes. Biochem Biophys Res Commun. 2012 Mar 16;419(3):573-7. doi: 10.1016/j.bbrc.2012.02.074.
7.Huang HY, Li X, Liu M, Song TJ, He Q, Ma CG, Tang QQ. Transcription factor YY1 promotes adipogenesis via inhibiting CHOP-10 expression. Biochem Biophys Res Commun. 2008 Oct 31;375(4):496-500. doi: 10.1016/j.bbrc.2008.07.151.
8.Wang SS, Huang HY, Chen SZ, Li X, Zhang WT, Tang QQ. Gdf6 induces commitment of pluripotent mesenchymal C3H10T1/2 cells to the adipocyte lineage. FEBS J. 2013 Mar 25. doi: 10.1111/febs.12256.
9.Liu Y, Zhang ZC, Qian SW, Zhang YY, Huang HY, Tang Y, Guo L, Li X, Tang QQ. MicroRNA-140 Promotes Adipocyte Lineage Commitment of C3H10T1/2 Pluripotent Stem Cells via Targeting Osteopetrosis-associated Transmembrane Protein 1. J Biol Chem. 2013; 288(12):8222-30. doi: 10.1074/jbc.M112.426163.
10.Qian SW, Tang Y, Li X, Liu Y, Zhang YY, Huang HY, Xue RD, Yu HY, Guo L, Gao HD, Liu Y, Sun X, Li YM, Jia WP, Tang QQ. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):E798-807. doi: 10.1073/pnas.1215236110.
11.Guo L, Li X, Huang JX, Huang HY, Zhang YY, Qian SW, Zhu H, Zhang YD, Liu Y, Liu Y, Wang KK, Tang QQ. Histone demethylase Kdm4b functions as a co-factor of C/EBPβ to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes. Cell Death Differ. 2012 Dec;19(12):1917-27. doi: 10.1038/cdd.2012.75. [PubMed - indexed for MEDLINE]
12.Zhang YY, Li X, Qian SW, Guo L, Huang HY, He Q, Liu Y, Ma CG, Tang QQ. Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis. Mol Endocrinol. 2012 May;26(5):798-808. doi: 10.1210/me.2011-1287.
13.Zhang YY, Li X, Qian SW, Guo L, Huang HY, He Q, Liu Y, Ma CG, Tang QQ. Transcriptional activation of histone H4 by C/EBPβ during the mitotic clonal expansion of 3T3-L1 adipocyte differentiation. Mol Biol Cell. 2011 Jul 1;22(13):2165-74. doi: 10.1091/mbc.E10-11-0912.
14.Qian SW, Li X, Zhang YY, Huang HY, Liu Y, Sun X, Tang QQ. Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow. BMC Dev Biol. 2010 May 7;10:47. doi: 10.1186/1471-213X-10-47.
15.Li X, Molina H, Huang H, Zhang YY, Liu M, Qian SW, Slawson C, Dias WB, Pandey A, Hart GW, Lane MD, Tang QQ. O-linked N-acetylglucosamine modification on CCAAT enhancer-binding protein beta: role during adipocyte differentiation. J Biol Chem. 2009 Jul 17;284(29):19248-54. doi: 10.1074/jbc.M109.005678.

 

主要承担课题
课题负责人在研的科研项目
课题来源            课题编号               
国家自然科学基金    81170781(面上项目)
国家自然科学基金    31271489(面上项目)

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