郭亮 副教授

 

    郭亮,博士,副教授,硕士生导师。2004年获得复旦大学上海医学院法医学专业学士学位。2009年复旦大学上海医学院生物化学与分子生物学专业毕业,获 博士学位。现任复旦大学基础医学院副教授。从事本科生和研究生的生物化学与分子生物学教学及科学研究工作。承担国家自然科学基金青年基金及面上项目。已发 表SCI论文10余篇,其中以第一作者在Cell Death Differ、Mol Cell Biol等生物化学领域有影响力的杂志上发表了研究性论文。

 

主要研究方向
脂肪细胞发育分化的分子机制以及肥胖相关代谢性疾病的分子机理研究。

 

代表性论文:
1.    Guo, L., Li, X., Huang, J. X., Huang, H. Y., Zhang, Y. Y., Qian, S. W., Zhu, H., Zhang, Y. D., Liu, Y., Wang, K. K., and Tang, Q. Q*.  Histone demethylase Kdm4b functions as a co-factor of C/EBPbeta to promote mitotic clonal expansion during differentiation of 3T3-L1 preadipocytes. Cell Death Differ. 2012;19, 1917-1927
2.    Guo, L (共同一作)., Huang, J. X., Liu, Y., Li, X., Zhou, S. R., Qian, S. W., Zhu, H., Huang, H. Y., Dang, Y. J., and Tang, Q. Q*. Transactivation of Atg4b by C/EBPbeta promotes autophagy to facilitate adipogenesis. Mol Cell Biol. 2013;33, 3180-3190
3.    Xie, J., Guo, L (共同一作)., Ruan, Y., Zhu, H., Wang, L., Zhou, L., Yun, X., and Gu, J*.  Laminarin-mediated targeting to Dectin-1 enhances antigen-specific immune responses. Biochem Biophys Res Commun. 2010;391, 958-962
4.     Guo, L., Xie, J., Ruan, Y., Zhou, L., Zhu, H., Yun, X., Jiang, Y., Lu, L., Chen, K., Min, Z., Wen, Y., and Gu, J*. Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum. Int Immunopharmacol.2009;9, 1175-1182
5.     Jiang, Y., Guo, L., Xie, L. Q., Zhang, Y. Y., Liu, X. H., Zhang, Y., Zhu, H., Yang, P. Y., Lu, H. J., and Tang, Q. Q*.  Proteome Profiling of Mitotic Clonal Expansion during 3T3-L1 Adipocyte Differentiation Using iTRAQ-2DLC-MS/MS. J Proteome Res(2014)
 6.    Li, S. F., Guo, L., Qian, S. W., Liu, Y., Zhang, Y. Y., Zhang, Z. C., Zhao, Y., Shou, J. Y., Tang, Q. Q., and Li, X*.  G9a is transactivated by C/EBPbeta to facilitate mitotic clonal expansion during 3T3-L1 preadipocyte differentiation. Am J Physiol Endocrinol Metab.2013;304, E990-998)
7.    Liu, Y., Zhang, Y. D., Guo, L., Huang, H. Y., Zhu, H., Huang, J. X., Zhou, S. R., Dang, Y. J., Li, X., and Tang, Q. Q*. Protein Inhibitor of Activated STAT 1 (PIAS1) Is Identified as the SUMO E3 Ligase of CCAAT/Enhancer-Binding Protein beta (C/EBPbeta) during Adipogenesis. Mol Cell Biol .2013;33, 4606-4617

 

主要承担课题
课题负责人在研的科研项目
课题来源                  课题编号
国家自然科学基金         31370027 (面上项目)  

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